He is also co-directing the Slovenian National registry of famil- ial hypercholesterolemia and rare dyslipidemias and serves as a National lead investigator at the EAS FHSC. In 2019, Dr. Ahmad was named a Texas Monthly Super Doctor Rising Star. Debra Duquette, M.S., C.G.C. Daniel Rader, MD is the Seymour Gray Professor of Molecular Medicine and Chair of the Department of Genetics at the Perelman School of Medicine. Assistant Professor of Medicine, Cardiovascular Medicine Fellowship Program They carry cholesterol through your blood. That said, there are a few situations where it may be best to routinely check lipoprotein(a) levels. LDL cholesterol is therefore considered the "bad" cholesterol. They occur in both soluble complexes—as in egg yolk and mammalian blood plasma —and insoluble ones, as in … You may have heard about Lipoprotein (a), Lp(a) or often referred to as âLp little a." In the community, Mrs. Harrison volunteers with the Sickle Cell Association of the National Capital Area, and is an active member of Metropolitan Baptist Church in Largo, MD. Dr. McGowan serves on the alumni board at the University of Massachusetts Medical Center and the National Lipid Association Foundation Board. LDL and HDL have different purposes: I view this as a continuum from Discovery > to the development of Model Systems > to clinical Translation > to larger Public Health efforts. Dr. Urh Groselj obtained MD and PhD degrees at the Faculty of Medicine, Uni- versity of Ljubljana and MA degree at the University of Leuven, Belgium. We have partnered with patients and organizations like the CDC, ACC and AHA to increase public health awareness of FH and have established and currently manage a national FH registry called âCASCADE FH.â, Massachusetts General Hospital Sometimes a clot can form and get stuck in the narrowed space, causing a heart attack or stroke. High levels of lipoprotein(a) are believed to be most damaging to arterial walls when a person's level of LDL (“bad”) cholesterol is also high. Professor of Vascular Medicine. He has been investigating cardiovascular genetics for 25 years with a focus on familial hypercholesterolemia (FH). Kathy Thompson is a volunteer FH Foundation Advocate for Awareness. Dr. Ahmad earned his medical degree at the Tulane University School of Medicine. Researchers are still working to understand lipoprotein(a) and the ways it may affect your health. LDL is called “bad cholesterol” because it takes cholesterol to your arteries, where it may collect in artery walls. He is also the Division Chief of Health Policy for the Department of Medical Ethics and Health Policy and a special advisor to the CEO of Penn Medicine and the Dean/EVP. FH Advocate for Awareness. For now, if you have FH, you should ask your health care practitioner to test your Lp(a) level, if you are found to have an elevated level, your first-degree relatives should also be screened and you should work to reduce all your modifiable risk factors especially your LDL cholesterol. More information is also available on the FH Foundationsâ website. A conjugated protein consisting of a simple protein combined with a fat (lipid) group. Ralph W. Muller is Executive Chairman of Seminal Health Fund (Philadelphia), National Advisor to Manatt, and Senior Fellow at LDI of Penn Medicine and Wharton (University of Pennsylvania). As part of her volunteerism with NSGC she founded the Cardiovascular Genetics Special Interest Group and the FH Working Group and is also their Cardiovascular Genetics Expert for the NSGC Expert Media Panel. He also serves as Chief of the Divisions of Human Genetics in the Departments of Medicine and Pediatrics. Dr. Lane-Fall is the founding Co-Director of the Penn Center for Perioperative Outcomes Research and Transformation. He has been elected to the National Academy of Medicine and the American Academy of Arts and Sciences. She has also served as a patient advocate in formal roles with the Sudden Arrhythmia Death Syndromes Foundation (SADS), where she was a member of both their Medical Education and Research Committees. Chief Scientific Advisor and Vice Chair of the Board of Directors, Perelman School of Medicine, University of Pennsylvania Section of Cardiology/Tulane University Heart & Vascular Institute. Director, Slovenian National Registry of Familial Hypercholesterolemia and Rare Dyslipidemias As a clinical geneticists, epidemiologist and nutritionist, Dr. Landry is focused on the engineering of equity-based systems engineering for clinical integration, translation, evaluation, optimization, and implementation of biomarkers. Duquette is currently the Genomics Coordinator at the Michigan Department of Health and Human Services. HDL (high-density lipoprotein), or “good” cholesterol, absorbs cholesterol and carries it back to the liver. JAMA 2009; 302:412-423. Since 2014 he works as a staff pediatrician at the Department of Pediatric Endocrinology, Diabetes and Metabolism, UMC – University Childrenâs Hospital Ljubljana, Slovenia. The reason this is not known (or rather, publicized) is that effective interventions go against the status quo of what constitutes a “heart healthy” diet. Apolipoprotein B (apoB) is a beta mobility; mostly be in low-density lipoprotein (LDL). Director of Cardiovascular Genomic Counseling. Dr. Rader has led pioneering studies of novel bio- logical pathways in lipid metabolism and heart disease revealed through genome-wide human genetics studies. There are two main types of cholesterol: High-density lipoprotein (HDL), or "good" cholesterol Low-density lipoprotein (LDL), or "bad" cholesterol. (The name of this glycoprotein is apolipoprotein(a).) Assistant Professor. A specific kind of protein, known as an apolipoprotein, bonds to a lipid through a covalent or noncovalent bond at the atomic level. She has also worked to raise awareness of FH in the NSGC community, by providing a Janus series lecture at the 2013 NSGC Annual Conference on FH, writing blogs about FH and cascade testing, among other activities. It’s often called the “bad cholesterol.” 2. Jennifer Moll, MS, PharmD, is a pharmacist actively involved in educating patients about the importance of heart disease prevention. He has also been a champion of âgenomic medicineâ and its potential benefits in guiding preventive therapies. Advancing optimum clinical care of FH through healthcare provider educational programs; Advocating for and shaping policies that impact the care of FH; and, Creating an international patient-facing Registry, accessible in multiple language. Dr. Eric Sijbrands is a professor of vascular medicine at the Erasmus MC in Rotterdam, the Netherlands. HDL takes LDL to your liver, where it’s flushed out of your body. Cholesterol Lp(a), Lp(a) What is this test? Laney K. Jones, PharmD, MPH, is an Assistant Professor in the Genomic Medicine Institute at Geisinger. Like high levels of LDL, high levels of Lp(a) can stick in your artery wall (called atherosclerosis), slowly blocking the artery. Very-low-density lipoprotein (VLDL), and; Chylomicron. She is currently an Assistant Professor at Howard University and teaches graduate students, medical students, and medical residents in various specialties, in the areas of genetics, genetic testing, genetic counseling and ethics. Lipoproteins are special particles made up of droplets of fats surrounded by a single layer of phospholipid molecules. He holds the Wolfe Distinguished Medical Research Chair, the Edith Schulich Vinet Chair in Human Genetics and the Blackburn Chair in Cardiovascular Research. She has held continuous peer-reviewed funding from multiple agencies including, CIHR, NIH and HSFC and has published over 260 manuscripts in peer-reviewed journals. She received her Doctor of Pharmacy degree from University of the Sciences in Philadelphia and her Master of Public Health from Mailman School of Public Health, Columbia University in New York City. What is Lipoprotein(a)? Chloe is a fellow of the Preventive Cardiovascular Nurses Association and serves as the president of the Crescent City (New Orleans) Chapter. Lipoprotein was discovered in 1963 by Kåre Berg. Patients with an identical FH mutation can have completely different prognoses. They have three children. Dr. McGowan lives in Bedford, NH with her husband. The FH Foundation Dr. Rader sees patients with lipid disorders and has been regularly recognized by Americaâs Top Doctors and Best Doctors in America. Duquette serves on the Executive Steering Committee for the PCORI funded American BRCA Outcomes & Utilization of Testing Network (ABOUT) Network, Facing Our Risk of Cancer Empowered (FORCE) Advisory Board, Institute of Medicine (IOM) Ovarian Cancer Research Committee, and eXamining Relevance of Articles for Young Survivors (XRAYS) Steering Committee. Rob Hegele is Distinguished University Professor of Medicine and Biochemistry, Western University and is Director of the London Regional Genomics Centre at Robarts Research Institute, all in in London, Ontario. Professor of Medicine His research program uses genetic variation as a tool to uncover new biology and enable enhanced clinical care informed by inherited susceptibility. Funded by the National Institutes of Health, Dr. Ahmad and his colleagues currently are working to identify families with these conditions in an effort to better understand their underlying genetic causes â and, ultimately, to improve patient outcomes. He is known for his work in the metabolism and function of HDL (the âgood cholesterolâ). Unfortunately the real dilemma falls to the patient who must do his or her own research and come up with a plan that suits. By using Verywell Health, you accept our, What You Need to Know About Arteriosclerosis, Low Cholesterol and Heart Disease With African Americans, What to Know about Very Low Density Lipoprotein, How Thyroid Disease Affects Cholesterol (and Vice Versa), Cholesterol & Triglycerides: What You Need to Know, How You or Your Doctor Can Determine Stroke Risk, Hyperlipidemia: Symptoms, Causes, Diagnosis, and Treatment, Preventing Heart Failure After Heart Attack. in biomedical engineering from the Tulane University School of Engineering. He has published >770 peer reviewed scientific papers. Dr. Musunuru received his M.D. What's a Desirable Level of Total Blood Cholesterol in Adults? Authoring 25 peer-reviewed publications, to date. Dr. Tsimikasâ clinical interests Vascular Medicine Program encompass treating patients in the continuum of high-risk primary prevention to endovascular intervention. Lp(a) is another type of ‘bad’ cholesterol. Her experiences with advanced and early heart disease led her to advocate for awareness by sharing her personal story. Among his scientific contributions, he pioneered use of a new approach to quantify genetic risk (âgenome-wide polygenic scoresâ) for common diseases, developed biomarkers that provide new biologic insights, and analyzed large-scale gene sequencing data to highlight key pathways driving risk for cardiometabolic disease. Made in your liver and then entering your bloodstream, lipoprotein(a) has been shown to build up under the inner lining of arteries. Genomics Coordinator, Northwestern Medicine Duquette received her Masters of Science in Genetic Counseling from Northwestern University. Professionally, she serves on the Diversity Task Force for the Accreditation Council of Genetic Counseling and is a member of the Prenatal Special Interest Group of the National Society of Genetic Counselors (NSGC). She is the author of numerous articles and five books. Lipoprotein is a low-density lipoprotein variant containing a protein called apolipoprotein. Chair, Department of Genetics. That’s because 1) not enough is known about lipoprotein(a)’s effect on heart health and 2) it’s found in only about 15% of the general population, with persons of non-Hispanic Caucasian, Chinese, and Japanese origins having the lowest levels. This means that unlike other cardiac risk factors, Lp(a) canât be modified by diet or exercise. Your level of Lp(a) is the same at age 5 as at age 45. Latrice Landry is a fellow specializing in precision medicine and health disparities at Harvard Medical School, Brigham and Womenâs Hospital, Dana Farber Cancer Institute and Harvard School of Public Health. Katherine Wilemon is the Founder, President & CEO of The FH Foundation, a leading research and advocacy non-profit organization focused on reducing heart disease by driving scientific under- standing and evidence-based care of familial hypercholesterolemia (FH). Amy is the 2018 President-Elect of the National Society of Genetic Counselors (https://www.nsgc.org/) and will serve as President of NSGC in 2019. I had heart attack at 52 , I am 56 . University of Texas Southwestern Medical Center She has authored many journal articles and is active in numerous committees. change diet ? This test measures the Lp(a) level in the blood to help evaluate your … Lipoproteins are the form in which lipids are transported in the blood. If you’re trying to lower your risk of developing heart disease, it’s best to put lipoprotein(a) on the treatment “back burner” for now and focus instead on methods for reducing the well-established risk factors for heart disease. It turns out that between a third and a half of people with FH also have an elevated Lp(a). High levels of low-density lipoprotein (LDL) can eventually build up within the walls of your blood vessels and narrow the passageways. He was recruited to Penn in 1994. Lipoprotein, any member of a group of substances containing both lipid (fat) and protein. A doctor may suggest an Lp(a) test know a person’s health in detail. Lipoprotein(a) as a Risk Factor for Heart Disease, Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved. She received a Master of Nursing from Louisiana State University Health Sciences Center and a Bachelor of Science in Nursing from Tuskegee University. He completed both a residency (internal medicine) and a fellowship (endocrinology and metabolism) at UT Southwestern Medical Center â training in cholesterol metabolism and genetics with mentors Drs. The rest is high-density lipoprotein (HDL) or “good” cholesterol. Associate Director of the Precision Medicine Unit, Broad Institute of MIT and Harvard She has both FH and significantly elevated Lipoprotein(a) and uses medications and Lipoprotein Apheresis to treat her cholesterol levels. The FH Foundation works in partnership with patients, clinicians, scientists and all participants in the healthcare ecosystem to develop inno- vative solutions that will overcome barriers to diagnosis, treatment and access. associate professor of cardiovascular medicine and genetics. Lipoproteins are the particles that transport cholesterol and triglycerides in the blood stream.Lipoproteins are composed of proteins (apolipoproteins), phospholipids, triglycerides and cholesterol.The lipoproteins vary in the major lipoprotein present and the relative contents of the different lipid components.Lp(a) is Conjugation with protein facilitates transport of lipids, which are hydrophobic, in the aqueous medium of the plasma. Lipoproteins are substances made of protein and fat that carry cholesterol through your bloodstream. They are a combination of fat (lipid) and protein. She is the Founder and Chair of the Lynch Syndrome Screening Network (LSSN), a network of 95 institutions teaming up to promote and establish universal screening for Lynch syndrome on all newly diagnosed colorectal and endometrial cancers. He has trained many physicians, medical students and graduate students. He joined the UT Southwestern faculty in 2010 and is American Board of Internal Medicine-certified in internal medicine, endocrinology, metabolism, and diabetes. Chloe currently holds a clinical faculty position with the Heart and Vascular Institute of Tulane University School of Medicine. In 2018, she graduated from the Harvard Medical Schoolâs Clinical Molecular Geneticsâ training program enabling her to integrate her biomarker expertise with direct patient care. They consist of a Triglyceride and Cholesterol center, surrounded by a phospholipid outer shell, with the hydrophilic portions oriented outward toward the surrounding water and lipophilic portions oriented inward toward the lipid center. Chloe Villavaso, MN, APRN, ACNS-BC, CMC, FPCNA is an individual with FH and Adult Health Clinical Nurse Specialist. It’s well known that low-density lipoprotein (LDL), or “bad cholesterol,” is a major cause of heart disease. She received her MD degree from Yale University, where she was elected to the Alpha Omega Alpha honor society. Unfortunately, at this point in time there are not a lot of medicines known to lower Lp(a). Both estrogen and niacin (a B vitamin) lower Lp(a) but have not been shown to protect people from developing heart disease. A new class of medications called PCSK9 inhibitors that came on the market in 2015, have been shown to lower Lp(a) modestly but more work needs to be done before they can be recommended to reduce Lp(a). Remnant cholesterol, also known as remnant lipoprotein, is a very atherogenic lipoprotein composed primarily of very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL). This collaborative is focused on developing tools and best practices for the identification and genetic testing of at-risk relatives of those diagnosed with three Tier 1 conditions: Hereditary Breast and Ovarian Cancer, Lynch syndrome, and FH. Kiran Musunuru is an associate professor of cardiovascular medicine and genetics at the Perelman School of Medicine at the University of Pennsylvania, where he has made outstanding research contributions in the use of gene editing to study and treat cardiovascular disease. In tandem with his research efforts he is co-leading a new Preventive Genomics Clinic at MGH to provide a clinical infrastructure for genome-first medicine. Perelman School of Medicine Perelman School of Medicine at the University of Pennsylvania Lipoprotein (a), or Lp (a) is a type of LDL. He was a past Commissioner of the Joint Commission (TJC) and. You may have heard of a ‘bad’ cholesterol called LDL. He obtained his MD degree in 1988 from the University of Massachusetts Medical School. He was honored with the Presidential Early Career Award for Scientists and Engineers from the White House in 2016, the American Heart Associationâs Award of Meritorious Achievement in 2016, and the American Philosophical Societyâs Judson Daland Prize for Outstanding Achievement in Clinical Investigation in 2018. lp(a) responds well to the intake of animal and dairy derived saturated fats. We are now creating human induced pluripotent stem cell (iPSC) lines to model the genetic networks that produce disease. What are some of the things that I can do ? (The name of this glycoprotein is apolipoprotein(a).). Abbreviated to Lp(a) and pronounced ‘L’ ‘P’ little ‘A’. Lp(a) is a type of low-density lipoprotein (LDL). His research aims to identify the causes of cholesterol and triglyceride disorders and to develop new treatment options for patients who suffer from them. As a research fellow in 1986 he applied DNA technologies in FH diagnosis. Her doctoral research focused on the interactions between diet and genetics as determinants for dyslipidemia in African Americans in the Jackson Heart Study. Mary McGowan received her medical degree from the University of Massachusetts. Lipoproteins are … Director of Vascular Medicine. The fat and protein molecules are bound together in different ways depending on the type of lipoprotein. He was first in North America to use five medications that are now routinely prescribed to treat high cholesterol and diabetes. Meghan Lane-Fall, MD, MSHP, FCCM is a physician-scientist committed to the provision of safe, effective patient care. Lipoprotein (a) includes a LDL particle bound to an apolipoprotein (a) – known as apo(a) – and apoB100. She employs qualitative and mixed methods to develop effective communication strategies that incorporate human factors principles while complementing clinician workflow. Statins effectively lower LDL, but raise lp(a). Dr. McPherson was elected to fellowship in the Royal Society of Canada in 2014. Assistant Director for Community Outreach and Education. In 2015, following her doctoral research she joined Harvard Medical Schoolâs Biomedical Informatics Fellowship Program to study information systems (clinical and bioinformatics) as tools for biomarker translation. He has been involved in several start-up biotech compa- nies related to his work. He also serves as a member of National Medical Ethics Committee. Saturated fats are potentially problematic unless consumed in the context of a low sugar/carbohydrate diet. Co-Director. The FH Foundation Her research interests include implementation science, familial hypercholesterolemia, and pharmacy services. In addition to her academic duties, she provides genetic counseling services at Howard University Hospital for a variety of referral reasons, in areas including prenatal (primary), pediatric, and adult genetics. LDL and HDL are two types of lipoproteins. Establishing FH Awareness Day (September 24) worldwide; Establishing and maintaining the national CASCADE FH Registry, in partnership with 40 clinical sites, to collect comprehensive longitudinal data to better understand outcomes of FH diagnosis and treatment; Creating an international patient-facing Registry, accessible in multiple languages; Applying cutting-edge informatics and big data through the FIND FH program to identify and reach the 90% of undiagnosed FH individuals; Hosting an annual FH Global Summit for scientists, physicians, thought leaders and key stake- holders to share insights and best practices. Levels of 100 to 129 mg/dL are acceptable for people with no health issues but may be of more concern for … He received his MD with Alpha Omega Alpha distinction from the Perelman School of Medicine at the University of Pennsylvania, and went on to complete clinical training in Internal Medicine and cardiology at Brigham and Women’s Hospital and MGH. 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